We use computer simulations of the brain to uncover the mechanisms responsible for normal brain function and neurological/psychiatric disease
Governing Hypotheses
Neuroanatomy and neurophysiology are critical: function follows forms through multiple scales from molecular to local connections (microconnectomics), to large-scale brain connectomics. Properties/pathology emerge at each scale.
There is no one brain code, but rather several codes that are important at different scales, as well as multiple codes that operate at the cell-spiking scale: rate codes, wave-front codes, synchrony codes etc.
Most brain disease occurs not through single dysfunction at a gene but through multiple causes. Dysfunctions occur at the level of genes, proteins, cells, tissue and networks. Disorders at one location at one scale set up cycles of effects.
