William Lytton

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2018
Mcdougal, R. A., Newton A., Hines M. L., & Lytton WW. (2018).  Building, simulating, and visualizing reaction-diffusion models with NEURON's enhanced rxd module. Society for Neuroscience 2018 (SFN '18).
Mulugeta, L., Drach A., Erdemir A., Hunt C. A., Horner M., Ku J. P., et al. (2018).  Credibility, Replicability, and Reproducibility in Simulation for Biomedicine and Clinical Applications in Neuroscience. Front. Neuroinform.. 12,
Graham, J. W., Angulo S., Gao P. P., Dura-Bernal S., Sivagnanam S., Hines M.., et al. (2018).  Embedded ensemble encoding: A hypothesis for reconciling cortical coding strategies. Society for Neuroscience 2018 (SFN '18).
Antic, S. D., Hines M., & Lytton WW. (2018).  Embedded ensemble encoding hypothesis: The role of the ``Prepared'' cell. J. Neurosci. Res..
Neymotin, S., Sherif M. A., Jung J. Q., Kabariti J. J., & Lytton WW. (2018).  Genome-wide associations of schizophrenia studied with computer simulation. (Cutsuridis, V., Graham BP., Cobb S., & Vida I., Ed.).Hippocampal Microcircuits: A Computational Modeler's Resource Book. 2,
Doherty, D. W., Dura-Bernal S., Neymotin S. A., & Lytton WW. (2018).  Identifying avalanches in simulated mouse primary motor cortex (M1). Society for Neuroscience 2018 (SFN '18).
Dura-Bernal, S., Neymotin S., Suter BA., Shepherd GMG., & Lytton WW. (2018).  Long-range inputs and H-current regulate different modes of operation in a multiscale model of mouse M1 microcircuits. bioRxiv.
Knox, A. T., Glauser T., Tenney J., Lytton WW., & Holland K. (2018).  Modeling pathogenesis and treatment response in childhood absence epilepsy. Epilepsia. 59, 135–145.
Lytton, WW. (2018).  Multiscale modeling of brain disease. Society for Neuroscience 2018 (SFN '18).
Newton, A., Seidenstein A. H., Hines M. L., Mcdougal R. A., & Lytton WW. (2018).  Multiscale simulation of spreading depolarization in ischemic stroke. Society for Neuroscience 2018 (SFN '18).
Dura-Bernal, S., Suter B. A., Quintana A., Cantarelli M., Gleeson P., Rodriguez F., et al. (2018).  NetPyNE: A GUI-based tool to build, simulate and analyze large-scale, data-driven network models in parallel NEURON. Society for Neuroscience 2018 (SFN '18).
Dura-Bernal, S., Gleeson P., Kerr C., Graham J., Quintana A., & Lytton WW. (2018).  Neurosim-lab/netpyne: v0.7.7.
Gao, P. P., Graham J. W., Angulo S. L., Dura-Bernal S., Hines M. L., Lytton WW., et al. (2018).  Recruitment of neurons into neural ensembles based on dendritic plateau potentials. Society for Neuroscience 2018 (SFN '18).
C Hunt, A., Erdemir A., Gabhann F. Mac, Lytton WW., Sander E. A., Transtrum M. K., et al. (2018).  The Spectrum of Mechanism-oriented Models for Explanations of Biological Phenomena.
2017
Neymotin, S., Dura-Bernal S., Moreno H., & Lytton WW. (2017).  Computer modeling for pharmacological treatments for dystonia. Drug Discov Today: Dis Model. In Press.
Lytton, WW. (2017).  Computer modeling of epilepsy: opportunities for drug discovery. Drug Discov Today: Dis Model. In press.
Newton, AJH., & Lytton WW. (2017).  Computer modeling of ischemic stroke. Drug Discov Today: Dis Model. 30, In press.
Lytton, WW. (2017).  Computers, causality and cure in epilepsy. Brain. 140, 516-519.
Angulo, S., Graham J. W., Gao P., Dura-Bernal S., Neymotin S. A., Antic S. D., et al. (2017).  Cortical ensembles based on dendritic plateau generation in the prefrontal cortex. Society for Neuroscience 2017 (SFN '17).
Gao, P., Graham J. W., Angulo S., Dura-Bernal S., Lytton WW., & Antic S. D. (2017).  Dendritic plateau generation model in cortical pyramidal neurons: A link to cortical ensembles. Society for Neuroscience 2017 (SFN '17).
Dura-Bernal, S., Neymotin S., Kerr CC., Sivagnanam S., Majumdar A., Francis JT., et al. (2017).  Evolutionary algorithm optimization of biological learning parameters in a biomimetic neuroprosthesis. IBM Journal of Research and Development. 61, 6–1.
Lin, Z., Tropper C., Yao Y., McDougal R. A., Patoary MN., Lytton WW., et al. (2017).  Load balancing for multi-threaded PDES of stochastic reaction-diffusion in neurons. J Simulation. 11, 267.
Dura-Bernal, S., Neymotin S. A., Suter B. A., Shepherd G. M., & Lytton WW. (2017).  Long-range inputs and H-current regulate different modes of operation in a multiscale model of mouse M1 microcircuits. Society for Neuroscience 2017 (SFN '17).
Womack, KB., Paliotta C., Strain JF., Ho JS., Skolnick Y., Lytton WW., et al. (2017).  Measurement of peripheral vision reaction time identifies white matter disruption in patients with mild traumatic brain injury. J Neurotrauma.
Newton, A., Mcdougal R. A., Hines M. L., Miyazaki K., Ross W. N., & Lytton WW. (2017).  Modeling electrodiffusion with the NEURON reaction-diffusion module. Society for Neuroscience 2017 (SFN '17).
Seidenstein, A., Newton A., Macdougal R. A., & Lytton WW. (2017).  Multiscale computer modeling of penumbral zones in brain ischemia. Society for Neuroscience 2017 (SFN '17).
Lytton, WW., Arle J., Bobashev G., Ji S., Klassen TL., Marmarelis VZ., et al. (2017).  Multiscale modeling in the clinic: diseases of the brain and nervous system. Brain Inform. 4, 219-230.
Lin, Z., Tropper C., McDougal R. A., Patoary M. Nazrul Ish, Lytton WW., Yao Y., et al. (2017).  Multithreaded Stochastic PDES for Reactions and Diffusions in Neurons. ACM Transactions on Modeling and Computer Simulation (TOMACS). 27, 7.
Neymotin, S., Suter BA., Dura-Bernal S., Shepherd GM., Migliore M., & Lytton WW. (2017).  Optimizing computer models of corticospinal neurons to replicate in vitro dynamics. J Neurophysiol. 117, 148-162.
Patoary, M. Nazrul Ish, Tropper C., McDougal R. A., Zhongwei L., & Lytton WW. (2017).  Parallel Stochastic discrete event simulation of calcium dynamics in neuron.. IEEE/ACM transactions on computational biology and bioinformatics.
Mcdougal, R. A., Newton A. J. H., Patoary M. N. I., Tropper C., Hines M. L., & Lytton WW. (2017).  Parallel stochastic spines in NEURON reaction-diffusion simulations. Society for Neuroscience 2017 (SFN '17).
Lytton, WW., Knox A., & Rosenthal J. J. C. (2017).  Site-directed mRNA editing of sodium channels has potential to alter neuronal firing and network dynamics: Computer models. Society for Neuroscience 2017 (SFN '17).
Neymotin, S., Talbot ZN., Jung JQ., Fenton AA., & Lytton WW. (2017).  Tracking recurrence of correlation structure in neuronal recordings. J Neurosci Methods. 275, 1-9.
2016
Neymotin, S. A., Dura-Bernal S., Suter B. A., Lakatos P., Shepherd G. M. G., & Lytton WW. (2016).  Beta oscillations in neocortex: A multiscale modeling study. Society for Neuroscience 2016 (SFN '16).
Sherif, M., & Lytton WW. (2016).  Brain Diseases. (Arbib, MA., & Bonaiuto JJ., Ed.).From Neuron to Cognition Via Computational Neuroscience. 673-692.
Neymotin, S., McDougal R. A., Bulanova AS., Zeki M., Lakatos P., Terman D., et al. (2016).  Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex. Neurosci. 316, 344-366.
Kerr, C., Dura-Bernal S., Menzies R. J., Mclauchlan C., Van Albada S. J., Kedziora D. J., et al. (2016).  Computational capacity as a function of network size. Society for Neuroscience 2016 (SFN '16).
Suter, B. A., Neymotin S. A., Shepherd G. M. G., & Lytton WW. (2016).  Dendritic morphology of corticospinal and crossed-corticostriatal neurons in mouse primary motor cortex. Society for Neuroscience 2016 (SFN '16).
Mcdougal, R. A., Tropper C., Hines M. L., & Lytton WW. (2016).  Expanding NEURON support for reaction-diffusion models. Society for Neuroscience 2016 (SFN '16).
Seidenstein, A., Mcdougal R. A., Hines M. L., & Lytton WW. (2016).  Mosaic multiscale computer modeling of ischemic stroke. Society for Neuroscience 2016 (SFN '16).
Neymotin, S., Dura-Bernal S., Lakatos P., Sanger TD., & Lytton WW. (2016).  Multitarget multiscale simulation for pharmacological treatment of dystonia in motor cortex. Front Pharmacol. 7, 157.
Dura-Bernal, S., BA S., Kerr C. C., Quintana A., Gleeson P., Shepherd GMG., et al. (2016).  NetPyNE: a Python package for NEURON to facilitate development and parallel simulation of biological neuronal networks. Computational Neuroscience.
McDougal, R. A., Bulanova AS., & Lytton WW. (2016).  Reproducibility in computational neuroscience models and simulations. {IEEE} Trans Biomed Eng. 63, 2021-2035.
Dura-Bernal, S., Li K., Neymotin S., Francis JT., Principe JC., & Lytton WW. (2016).  Restoring behavior via inverse neurocontroller in a lesioned cortical spiking model driving a virtual arm. Front Neurosci. 10, 28.
Sherif, M. A., Neymotin S. A., & Lytton WW. (2016).  Schizophrenia genome-wide association studied with computer simulation: gamma oscillations and information flow in CA3. Society for Neuroscience 2016 (SFN '16).
Lytton, WW., Seidenstein AH., Dura-Bernal S., McDougal R. A., Schürmann F., & Hines ML. (2016).  Simulation neurotechnologies for advancing brain research: parallelizing large networks in NEURON. Neural Comput. 28, 2063-2090.
2015
Lytton, WW., & Drongelen W. (2015).  Beyond the canon: temporal and spatial multiscale organization in cortex. Computational Neuroscience Meeting Workshop.
Sherif, M. A., Skosnik P., Hajs M., & Lytton WW. (2015).  Computer model of endocannabinoid effects in CA3. Society for Neuroscience 2015 (SFN '15).
Seidenstein, AH., Barone FC., & Lytton WW. (2015).  Computer modeling of ischemic stroke. Scholarpedia. 10, 32015; revision \#148671; Accessed Oct 12, 2015.
Dura-Bernal, S., Zhou X., Neymotin S., Przekwas A., Francis J. T., & Lytton WW. (2015).  Cortical spiking network interfaced with virtual musculoskeletal arm and robotic arm. Frontiers in Neurorobotics. 9,
Dura-Bernal, S., Majumdar A., Neymotin S., Sivagnanam S., Francis J. T., & Lytton WW. (2015).  A dynamic data-driven approach to closed-loop neuroprosthetics based on multiscale biomimetic brain models. IEEE Interanationl Conference on High Performance Computing 2015 Workshop: InfoSymbiotics/Dynamic Data Driven Applications Systems (DDDAS) for Smarter Systems, Bangalore, India.
Mcdougal, R. A., Bulanova A. S., Hines M. L., & Lytton WW. (2015).  Hybrid 1d/3d reaction-diffusion in the neuron simulator. Society for Neuroscience 2015 (SFN '15).
Dura-Bernal, S., Kerr C., Neymotin S., Suter B., Shepherd G., Francis J., et al. (2015).  Large-scale M1 microcircuit model with plastic input connections from biological PMd neurons used for prosthetic arm control. 24th Annual Computational Neuroscience Meeting (CNS15).
Neymotin, SA., Salvador D-B., Suter BA., Migliore M., Shepherd GMG., & Lytton WW. (2015).  Microconnectomics of primary motor cortex: a multiscale computer model. Multiscale Modeling. National Institutes of Health.
Neymotin, SA., BA S., Migliore M., Salvador D-B., Shepherd GMG., & Lytton WW. (2015).  Motor cortex neurons: from experiment to model via evolutionary algorithms. Computational Neuroscience.
Lytton, WW., Vadigepalli R., & Kramer MA. (2015).  Multiscale Computational Modeling for the US BRAIN initiative.
Neymotin, S., McDougal R. A., Sherif MA., Fall CP., Hines ML., & Lytton WW. (2015).  Neuronal calcium wave propagation varies with changes in endoplasmic reticulum parameters: a computer model. Neural Comput. 27, 898–924.
Seidenstein, A., Neymotin S. A., Fesharaki A., Hines M. L., Mcdougal R. A., Bulanova A. S., et al. (2015).  Neuronal network bump attractors augmented by calcium up-regulation of Ih in a multiscale computer model of prefrontal cortex. Society for Neuroscience 2015 (SFN '15).
Dura-Bernal, S., Suter B. A., Neymotin S. A., Quintana A., Gleeson P., Sheperd G. M. G., et al. (2015).  Normalized cortical depth (NCD) as a primary coordinate system for cell connectivity in cortex: experiment and model. Society for Neuroscience 2015 (SFN '15).
Lin, Z., Tropper C., Patoary M. Nazrul Ish, McDougal R. A., Lytton WW., & Hines M. L. (2015).  Ntw-mt: A multi-threaded simulator for reaction diffusion simulations in neuron. Proceedings of the 3rd ACM SIGSIM Conference on Principles of Advanced Discrete Simulation. 157–167.
Neymotin, SA., Suter BA., Migliore M., Salvador D-B., Shepherd GMG., & Lytton WW. (2015).  Optimizing computer models of layer 5 motor cortex pyramidal neurons using somatic whole-cell recordings. Society for Neuroscience.
Tropper, C., Zhongwei L., Mcdougal R. A., Hines M., & Lytton WW. (2015).  Parallel reaction-diffusion simulation in NEURON. Society for Neuroscience 2015 (SFN '15).
Seidenstein, A. H., McDougal R. A., Hines M. L., & Lytton WW. (2015).  Parallelizing large networks using NEURON-Python. BMC Neuroscience.
Li, K., Dura-Bernal S., Francis J., Lytton WW., & Principe J. (2015).  Repairing Lesions via Kernel Adaptive Inverse Control in a Biomimetic Model of Sensorimotor Cortex. Neural Engineering (NER), 2015 7th International IEEE/EMBS Conference. 1-4.
Choi, J. S., Menzies R. J., Dura-Bernal S., Francis J. T., Lytton WW., & Kerr C. C. (2015).  Spiking network modeling of neuronal dynamics in individual rats. BMC Neuroscience.
Erdemir, A., Mulugeta L., & Lytton WW. (2015).  Ten "not so simple" rules for credible practice of modeling & simulation in healthcare. Frontiers in Medical Devices Meeting.
2014
Mcdougal, R. A., Hines M. L., & Lytton WW. (2014).  Calcium 'impedance mismatch' – the role of geometry on diffusion dynamics. Society for Neuroscience 2014 (SFN '14).
Neymotin, S., McDougal R. A., Hines ML., & Lytton WW. (2014).  Calcium regulation of HCN supports persistent activity associated with working memory: a multiscale model of prefrontal cortex. BMC Neuroscience. 15, P108.
Neymotin, S. A., Mcdougal R. A., Hines M. L., & Lytton WW. (2014).  Calcium regulation of HCN supports persistent activity associated with working memory: A multiscale model of prefrontal cortex. Society for Neuroscience 2014 (SFN '14).
Rowan, MS., Neymotin S., & Lytton WW. (2014).  Electrostimulation to reduce synaptic scaling driven progression of Alzheimer's disease. Front Comput Neurosci. 8, 39.
Dura-Bernal, S., Prins N., Neymotin S., Prasad A., Sanchez J., Francis JT., et al. (2014).  Evaluating Hebbian reinforcement learning BMI using an in silico brain model and a virtual musculoskeletal arm.. Neural Control of Movement.
Kerr, C. C., O'Shea D. J., Goo W., Dura-Bernal S., Diester I., Kalanithi P., et al. (2014).  Information flow in optogenetically stimulated macaque motor cortex: simulation and experiment. Neural Control of Movement (NCM) meeting.
Bulanova, AS., McDougal RA., Neymotin SA., Mutai V., Lytton WW., & Hines M. (2014).  Integrating Systems Biology Markup Language (SBML) with NEURON. Computational Neuroscience.
Bulanova, A. S., Mcdougal R. A., Neymotin S. A., Mutai V. K., Lytton WW., & Hines M. L. (2014).  Integrating Systems Biology Markup Language (SBML) with NEURON. Society for Neuroscience 2014 (SFN '14).
McDougal, RA., Hines ML., & Lytton WW. (2014).  A method for multi-simulator reaction-diffusion with NEURON. Computational Neuroscience.